Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: Evidence grom genome-wide analysis Academic Article uri icon

Overview

MeSH Major

  • Genetic Predisposition to Disease
  • Granulomatosis with Polyangiitis
  • HLA-DP beta-Chains
  • Polymorphism, Single Nucleotide
  • Semaphorins

abstract

  • We identified the SEMA6A and HLA-DP loci as significant contributors to risk for GPA, with the HLA-DPB1*04 allele almost completely accounting for the MHC association. These two associations confirm the critical role of immunogenetic factors in the development of GPA.

authors

publication date

  • August 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4471994

Digital Object Identifier (DOI)

  • 10.1002/art.38036

PubMed ID

  • 23740775

Additional Document Info

start page

  • 2457

end page

  • 68

volume

  • 65

number

  • 9