Emerging treatments for chronic constipation Review uri icon

Overview

MeSH Major

  • Constipation

abstract

  • While undoubtedly effective, high-quality evidence to support laxatives, the traditional remedies for constipation, is remarkably scarce due, in large part, to the absence, until very recently, of high-quality randomized controlled clinical trials. The selective prokinetic agent prucalopride and the prosecretory agents lubiprostone and linaclotide have shown efficacy and been associated with a good safety record in large well-conducted clinical studies. Other novel approaches, such as the inhibition of ileal bile salt absorption, offer particular promise.

publication date

  • September 2013

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1517/14728214.2013.831068

PubMed ID

  • 23957819

Additional Document Info

start page

  • 365

end page

  • 73

volume

  • 18

number

  • 3