Mitochondria: sensors and mediators of innate immune receptor signaling. Review uri icon

Overview

MeSH

  • Animals
  • Humans

MeSH Major

  • Immunity, Innate
  • Mitochondria
  • Receptors, Pattern Recognition
  • Signal Transduction

abstract

  • By integrating stress signals with inputs from other cellular organelles, eukaryotic mitochondria are dynamic sensing systems that can confer substantial impact on innate immune signaling in both health and disease. This review highlights recently discovered elements of innate immune receptor signaling (TLR, RLR, NLR, and CLR) associated with mitochondrial function and discusses the role of mitochondria in the initiation and/or manifestation of inflammatory diseases and disorders. We also highlight the role of mitochondria as therapeutic targets for inflammatory disease. Copyright © 2013 Elsevier Ltd. All rights reserved.

publication date

  • June 2013

has subject area

  • Animals
  • Humans
  • Immunity, Innate
  • Mitochondria
  • Receptors, Pattern Recognition
  • Signal Transduction

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.mib.2013.05.005

PubMed ID

  • 23757367

Additional Document Info

start page

  • 327

end page

  • 338

volume

  • 16

number

  • 3