Translational developmental studies of stress on brain and behavior: Implications for adolescent mental health and illness? Review uri icon


MeSH Major

  • Adolescent Behavior
  • Brain
  • Mental Disorders
  • Mental Health
  • Stress, Psychological
  • Translational Medical Research


  • Adolescence is the transition from childhood to adulthood, with onset marked by puberty and the offset by relative independence from parents. Across species, it is a time of incredible change that carries increased risks and rewards. The ability of the individual to respond adequately to the mental, physical and emotional stresses of life during this time is a function of both their early environment and their present state. In this article, we focus on the effects that acute threat and chronic stress have on the brain and behavior in humans and rodents. First, we highlight developmental changes in frontolimbic function as healthy individuals transition into and out of adolescence. Second, we examine genetic factors that may enhance susceptibility to stress in one individual over another using translation from genetic mouse models to human neuroimaging. Third, we examine how the timing and nature of stress varies in its impact on brain and behavior. These findings are discussed in the context of implications for adolescent mental health and illness.

publication date

  • February 25, 2013



  • Review



  • eng

PubMed Central ID

  • PMC3696429

Digital Object Identifier (DOI)

  • 10.1016/j.neuroscience.2013.01.023

PubMed ID

  • 23340244

Additional Document Info

start page

  • 53

end page

  • 62


  • 249