Epigenetic therapy in non-small-cell lung cancer: Targeting DNA methyltransferases and histone deacetylases Review uri icon

Overview

MeSH Major

  • Carcinoma, Non-Small-Cell Lung
  • DNA Modification Methylases
  • Epigenesis, Genetic
  • Histone Deacetylase Inhibitors
  • Lung Neoplasms

abstract

  • Combinatorial epigenetic therapy has demonstrated encouraging clinical activity, but many relevant questions remain. Global strategies influencing the epigenome may have both positive and potential negative long-term effects on cancer progression. Further clinical investigation of this approach, including exploratory studies to define predictive biomarkers, is warranted.

publication date

  • September 2013

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1517/14712598.2013.819337

PubMed ID

  • 23859704

Additional Document Info

start page

  • 1273

end page

  • 85

volume

  • 13

number

  • 9