Immunological insights from patients undergoing surgery on ipilimumab for metastatic melanoma Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Immunotherapy
  • Lymphocytes, Tumor-Infiltrating
  • Melanoma
  • Skin Neoplasms
  • T-Lymphocytes, Regulatory

abstract

  • Surgery for patients on ipilimumab is safe. This study highlights the immunosuppressive phenotype in tumors not responding to immunotherapy. The high percentage of T-regulatory cells and low T-effector cells in progressive tumors suggests a possible mechanism of immune escape.

publication date

  • September 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1245/s10434-013-2999-1

PubMed ID

  • 23681603

Additional Document Info

start page

  • 3106

end page

  • 11

volume

  • 20

number

  • 9