ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: An analysis of 1,683 patients with non-small cell lung cancer Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Non-Small-Cell Lung
  • Drug Resistance, Neoplasm
  • Proto-Oncogene Proteins
  • Pyrazoles
  • Pyridines
  • Receptor, Epidermal Growth Factor
  • ras Proteins

abstract

  • Functional ALK rearrangements were mutually exclusive with EGFR and KRAS mutations in a large Western patient population. This lack of overlap was also observed in ALK-positive cancers with acquired resistance to crizotinib.

publication date

  • August 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3874127

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-13-0318

PubMed ID

  • 23729361

Additional Document Info

start page

  • 4273

end page

  • 81

volume

  • 19

number

  • 15