ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: An analysis of 1,683 patients with non-small cell lung cancer
Academic Article
Overview
MeSH Major
Carcinoma, Non-Small-Cell Lung
Drug Resistance, Neoplasm
Proto-Oncogene Proteins
Pyrazoles
Pyridines
Receptor, Epidermal Growth Factor
ras Proteins
abstract
Functional ALK rearrangements were mutually exclusive with EGFR and KRAS mutations in a large Western patient population. This lack of overlap was also observed in ALK-positive cancers with acquired resistance to crizotinib.
