Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers Academic Article uri icon

Overview

MeSH Major

  • Lung Neoplasms
  • Pneumonia
  • Sarcoidosis, Pulmonary
  • Transcriptome
  • Tuberculosis, Pulmonary

abstract

  • Tuberculosis and sarcoidosis revealed similar blood transcriptional profiles, dominated by interferon-inducible transcripts, while pneumonia and lung cancer showed distinct signatures, dominated by inflammatory genes. There were also significant differences between tuberculosis and sarcoidosis in the degree of their transcriptional activity, the heterogeneity of their profiles and their transcriptional response to treatment.

publication date

  • August 5, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3734176

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0070630

PubMed ID

  • 23940611

Additional Document Info

start page

  • e70630

volume

  • 8

number

  • 8