Lipoprotein receptor-related protein-6 protects the brain from ischemic injury Academic Article uri icon

Overview

MeSH Major

  • Brain
  • Brain Ischemia
  • Low Density Lipoprotein Receptor-Related Protein-6

abstract

  • LRP6 activates an endogenous neuroprotective pathway that acts independently of β-catenin by controlling GSK-3β activity and preventing its deleterious mitochondrial and proinflammatory effects. The findings raise the possibility that emerging treatment strategies for diseases attributable to LRP6 loss-of-function mutations could also lead to new therapeutic avenues for ischemic stroke.

publication date

  • August 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3933931

Digital Object Identifier (DOI)

  • 10.1161/STROKEAHA.113.001320

PubMed ID

  • 23743975

Additional Document Info

start page

  • 2284

end page

  • 91

volume

  • 44

number

  • 8