An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells Academic Article uri icon

Overview

MeSH Major

  • Surgical Instruments
  • Sutures

abstract

  • One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.

publication date

  • January 2013

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.4161/onco.22409

Additional Document Info

start page

  • e22409

volume

  • 2

number

  • 1