TMPRSS2-ERG rearrangement in dominant anterior prostatic tumours: Incidence and correlation with ERG immunohistochemistry Academic Article uri icon

Overview

MeSH Major

  • Gene Rearrangement
  • Oncogene Proteins, Fusion
  • Prostatic Neoplasms
  • Serine Endopeptidases
  • Trans-Activators

abstract

  • TMPRSS2-ERG rearrangement occurs in dominant TZ and anterior PZ prostate cancers, with all rearranged TZ cancers in this cohort showing deletion. ERG immunohistochemistry demonstrated excellent sensitivity (86%) and specificity (96%) for TMPRSS2-ERG rearrangement. TMPRSS2-ERG fusion is rare in TZ tumours and present at a low frequency in tumours displaying 'clear cell' histology.

publication date

  • August 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3723763

Digital Object Identifier (DOI)

  • 10.1111/his.12153

PubMed ID

  • 23701505

Additional Document Info

start page

  • 279

end page

  • 86

volume

  • 63

number

  • 2