A novel channelopathy in pulmonary arterial hypertension Academic Article uri icon

Overview

MeSH Major

  • Channelopathies
  • Hypertension, Pulmonary
  • Mutation, Missense
  • Nerve Tissue Proteins
  • Potassium Channels, Tandem Pore Domain

abstract

  • Our study identified the association of a novel gene, KCNK3, with familial and idiopathic pulmonary arterial hypertension. Mutations in this gene produced reduced potassium-channel current, which was successfully remedied by pharmacologic manipulation. (Funded by the National Institutes of Health.)

publication date

  • August 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3792227

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa1211097

PubMed ID

  • 23883380

Additional Document Info

start page

  • 351

end page

  • 61

volume

  • 369

number

  • 4