Heterogeneity of tumor-induced gene expression changes in the human metabolic network Academic Article uri icon


MeSH Major

  • Cell Transformation, Neoplastic
  • Isocitrate Dehydrogenase
  • Metabolic Networks and Pathways
  • Neoplasms


  • Reprogramming of cellular metabolism is an emerging hallmark of neoplastic transformation. However, it is not known how the expression of metabolic genes in tumors differs from that in normal tissues, or whether different tumor types exhibit similar metabolic changes. Here we compare expression patterns of metabolic genes across 22 diverse types of human tumors. Overall, the metabolic gene expression program in tumors is similar to that in the corresponding normal tissues. Although expression changes of some metabolic pathways (e.g., upregulation of nucleotide biosynthesis and glycolysis) are frequently observed across tumors, expression changes of other pathways (e.g., oxidative phosphorylation) are very heterogeneous. Our analysis also suggests that the expression changes of some metabolic genes (e.g., isocitrate dehydrogenase and fumarate hydratase) may enhance or mimic the effects of recurrent mutations in tumors. On the level of individual biochemical reactions, many hundreds of metabolic isoenzymes show significant and tumor-specific expression changes. These isoenzymes are potential targets for anticancer therapy.

publication date

  • June 2013



  • Academic Article



  • eng

PubMed Central ID

  • PMC3681899

Digital Object Identifier (DOI)

  • 10.1038/nbt.2530

PubMed ID

  • 23604282

Additional Document Info

start page

  • 522

end page

  • 9


  • 31


  • 6