Langerhans-type and monocyte-derived human dendritic cells have different susceptibilities to mRNA electroporation with distinct effects on maturation and activation: Implications for immunogenicity in dendritic cell-based immunotherapy Academic Article uri icon

Overview

MeSH Major

  • Dendritic Cells
  • Electroporation
  • Islets of Langerhans
  • Monocytes
  • Transfection

abstract

  • These findings support mRNA electroporation of DCs, and in particular LCs, as an effective non-viral method to stimulate specific, potent CD8+ CTL responses. The differences between LCs and moDCs regarding this form of antigen-loading have important implications for DC-based immunotherapies.

publication date

  • July 9, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3710267

Digital Object Identifier (DOI)

  • 10.1186/1479-5876-11-166

PubMed ID

  • 23837662

Additional Document Info

start page

  • 166

volume

  • 11

number

  • 1