COMPLEXO: Identifying the missing heritability of breast cancer via next generation collaboration Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Genetic Predisposition to Disease

abstract

  • Linkage analysis, positional cloning, candidate gene mutation scanning and genome-wide association study approaches have all contributed significantly to our understanding of the underlying genetic architecture of breast cancer. Taken together, these approaches have identified genetic variation that explains approximately 30% of the overall familial risk of breast cancer, implying that more, and likely rarer, genetic susceptibility alleles remain to be discovered.

authors

publication date

  • June 21, 2013

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1186/bcr3434

Additional Document Info

start page

  • 402

volume

  • 15

number

  • 3