Exogenous Glucose Administration Impairs Glucose Tolerance and Pancreatic Insulin Secretion during Acute Sepsis in Non-Diabetic Mice Academic Article uri icon

Overview

MeSH Major

  • Diabetes Mellitus, Experimental
  • Glucose
  • Insulin
  • Pancreas
  • Sepsis

abstract

  • The combination of parenteral glucose support and the systemic inflammatory response in the acute phase of sepsis induces profound insulin resistance and impairs compensatory pancreatic insulin secretion, leading to the development of fulminant hyperglycemia.

publication date

  • June 24, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3691245

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0067716

PubMed ID

  • 23826335

Additional Document Info

start page

  • e67716

volume

  • 8

number

  • 6