Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: A report by MSKCC and the KIRC TCGA research network Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Renal Cell
  • Histone-Lysine N-Methyltransferase
  • Kidney Neoplasms
  • Tumor Suppressor Proteins
  • Ubiquitin Thiolesterase

abstract

  • The chromosome 3p21 locus harbors 3 frequently mutated ccRCC tumor suppressor genes. BAP1 and SETD2 mutations (6%-12%) are associated with worse CSS, suggesting their roles in disease progression. PBRM1 mutations (30%-34%) do not impact CSS, implicating its principal role in the tumor initiation. Future efforts should focus on therapeutic interventions and further clinical, pathologic, and molecular interrogation of this novel class of tumor suppressors.

publication date

  • June 15, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3708609

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-12-3886

PubMed ID

  • 23620406

Additional Document Info

start page

  • 3259

end page

  • 67

volume

  • 19

number

  • 12