The PPARĪ³ agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model
Academic Article
Overview
MeSH Major
Blood-Brain Barrier
Brain Neoplasms
Glioma
PPAR gamma
Thiazolidinediones
abstract
These data indicate that pioglitazone crosses the blood-brain barrier and has antineoplastic effects in this glioma xenograft model and may be of potential use in treatment of malignant gliomas.
