The PPARĪ³ agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model Academic Article uri icon

Overview

MeSH Major

  • Blood-Brain Barrier
  • Brain Neoplasms
  • Glioma
  • PPAR gamma
  • Thiazolidinediones

abstract

  • These data indicate that pioglitazone crosses the blood-brain barrier and has antineoplastic effects in this glioma xenograft model and may be of potential use in treatment of malignant gliomas.

publication date

  • April 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1007/s00280-013-2084-2

PubMed ID

  • 23358645

Additional Document Info

start page

  • 929

end page

  • 36

volume

  • 71

number

  • 4