Metal-conjugated affinity labels: A new concept to create enantioselective artificial metalloenzymes Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Glioblastoma
  • Green Fluorescent Proteins
  • Neuroimaging
  • Phthalazines
  • Piperazines
  • Poly(ADP-ribose) Polymerase Inhibitors

abstract

  • How to train a protein: Metal-conjugated affinity labels were used to selectively position catalytically active metal centers in the binding pocket of proteases. The resulting artificial metalloenzymes achieve up to 82% e.r. in the hydrogenation of ketones. The modular setup enables a rapid generation of artificial metalloenzyme libraries, which can be adapted to a broad range of catalytic conditions. © 2013 The Authors.

publication date

  • April 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3646430

Digital Object Identifier (DOI)

  • 10.1002/open.201200044

PubMed ID

  • 24551533

Additional Document Info

start page

  • 50

end page

  • 4

volume

  • 2

number

  • 2