Metal-conjugated affinity labels: A new concept to create enantioselective artificial metalloenzymes
Green Fluorescent Proteins
Poly(ADP-ribose) Polymerase Inhibitors
How to train a protein: Metal-conjugated affinity labels were used to selectively position catalytically active metal centers in the binding pocket of proteases. The resulting artificial metalloenzymes achieve up to 82% e.r. in the hydrogenation of ketones. The modular setup enables a rapid generation of artificial metalloenzyme libraries, which can be adapted to a broad range of catalytic conditions. © 2013 The Authors.
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