Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models
Antineoplastic Agents, Alkylating
DNA Modification Methylases
DNA Repair Enzymes
Tumor Suppressor Proteins
Across the 7 tumor models studied, there was no consistent difference between protracted and standard TMZ regimens. The efficacy of protracted TMZ regimens may be limited in a subset of MGMT unmethylated tumors by induction of MGMT expression.