Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents, Alkylating
  • Brain Neoplasms
  • DNA Methylation
  • DNA Modification Methylases
  • DNA Repair Enzymes
  • Dacarbazine
  • Glioblastoma
  • Tumor Suppressor Proteins

abstract

  • Across the 7 tumor models studied, there was no consistent difference between protracted and standard TMZ regimens. The efficacy of protracted TMZ regimens may be limited in a subset of MGMT unmethylated tumors by induction of MGMT expression.

publication date

  • June 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3661094

Digital Object Identifier (DOI)

  • 10.1093/neuonc/not010

PubMed ID

  • 23479134

Additional Document Info

start page

  • 735

end page

  • 46

volume

  • 15

number

  • 6