Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors Review uri icon

Overview

MeSH Major

  • Neoplasms

abstract

  • Children with solid tumors, most of which are malignant, have an excellent prognosis when treated on contemporary regimens. These regimens, which incorporate chemotherapeutic agents and treatment modalities used for many decades, have evolved to improve relapse-free survival and reduce long-term toxicity. This review discusses the evolution of the treatment regimens employed for management of the most common solid tumors, emphasizing the similarities between contemporary and historical regimens. These similarities allow the use of historical patient cohorts to identify the late effects of successful therapy and to evaluate remedial interventions for these adverse effects.

publication date

  • July 2013

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3810072

Digital Object Identifier (DOI)

  • 10.1002/pbc.24487

PubMed ID

  • 23418018

Additional Document Info

start page

  • 1083

end page

  • 94

volume

  • 60

number

  • 7