Phantosmia during radiation therapy: A Report of 2 Cases Academic Article uri icon

Overview

MeSH Major

  • Astrocytoma
  • Brain Neoplasms
  • Brain Stem Neoplasms
  • Glioma
  • Neoplasms, Neuroepithelial
  • Olfaction Disorders
  • Radiotherapy

abstract

  • Phantosmia is an infrequently reported and poorly understood qualitative olfactory disorder characterized by the perception of a frequently unpleasant odor in the absence of an odorant stimulus. Peripheral phantosmia is hypothesized to involve abnormally active olfactory receptor neurons while central phantosmia is theorized to be the result of hyperactive neurons in the cortex. The authors present a case report that describes 2 patients with incomparable tumors and radiation fields who both experienced phantosmia featuring a halitosis-like odor during their courses of radiation therapy. Both the 6-year-old with diffuse intrinsic pontine glioma and the 15-year-old with World Health Organization grade II-III astrocytoma in the bifrontal lobes experienced significant distress and decreased quality of life during treatment because of the phantosmia, which resolved after completion of radiation therapy. To the best of the authors' knowledge, these are the first descriptions of phantosmia during focal or whole-brain radiation therapy.

publication date

  • June 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1177/0883073812450616

PubMed ID

  • 22805250

Additional Document Info

start page

  • 791

end page

  • 4

volume

  • 28

number

  • 6