Targeting bone physiology for the treatment of metastatic prostate cancer Review uri icon

Overview

MeSH Major

  • Bone Neoplasms
  • Bone and Bones
  • Prostatic Neoplasms

abstract

  • Metastatic prostate cancer has a unique predilection for bone that can lead to significant clinical sequelae, such as fracture and cord compression. This tropism for bone yields not only clinical challenges, but also opportunities to understand the tumor biology in bone and to develop relevant therapeutic strategies. The process by which tumor cells migrate to bone, remain dormant, and then colonize and expand is based on complex interactions between prostate cancer tumor cells and the host microenvironment. This review will provide an overview of these interactions as well as therapies targeting osseous metastases in castration-resistant prostate cancer.

publication date

  • March 2013

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3938391

PubMed ID

  • 23598981

Additional Document Info

start page

  • 134

end page

  • 43

volume

  • 11

number

  • 3