Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1 Academic Article uri icon

Overview

MeSH Major

  • Antigens, CD11b
  • Antigens, Ly
  • Neoplasms
  • Thrombospondin 1

abstract

  • The mechanisms of metastasis suppression are poorly understood. Here, we have identified a novel mechanism whereby metastasis-incompetent tumors generate metastasis-suppressive microenvironments in distant organs by inducing Tsp-1 expression in the bone marrow–derived Gr1+myeloid cells. A 5-amino acid peptide with Tsp-1–inducing activity was identified as a therapeutic agent against metastatic cancer.

publication date

  • May 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3672408

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-12-0476

PubMed ID

  • 23633432

Additional Document Info

start page

  • 578

end page

  • 89

volume

  • 3

number

  • 5