TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia Academic Article uri icon

Overview

MeSH Major

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
  • Proto-Oncogene Proteins c-bcl-2
  • STAT1 Transcription Factor
  • TYK2 Kinase

abstract

  • In recent years, "pathway dependence" has been revealed in specific types of human cancer, which can be important because they pinpoint proteins that are particularly vulnerable to antitumor-targeted inhibition (so-called Achilles’ heel proteins). Here, we use RNAi technology to identify a novel oncogenic pathway that involves aberrant activation of the TYK2 tyrosine kinase and its downstream substrate, STAT1, which ultimately promotes T-ALL cell survival through the upregulation of BCL2 expression

publication date

  • May 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3651770

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-12-0504

PubMed ID

  • 23471820

Additional Document Info

start page

  • 564

end page

  • 77

volume

  • 3

number

  • 5