Incidence and predictors of secondary fibromyalgia in an early arthritis cohort. Academic Article uri icon

Overview

MeSH

  • Adult
  • Aged
  • Antibodies
  • Arthritis
  • Canada
  • Cohort Studies
  • Female
  • Humans
  • Incidence
  • Male
  • Mental Disorders
  • Middle Aged
  • Pain Measurement
  • Peptides, Cyclic
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Severity of Illness Index

MeSH Major

  • Arthritis, Rheumatoid
  • Fibromyalgia

abstract

  • Secondary fibromyalgia (FM) is common among patients with inflammatory arthritis, but little is known about its incidence and the factors leading to its development. The authors examined the incidence of secondary FM in an early inflammatory arthritis cohort, and assessed the association between pain, inflammation, psychosocial variables and the clinical diagnosis of FM. Data from 1487 patients in the Canadian Early Arthritis Cohort, a prospective, observational Canadian cohort of early inflammatory arthritis patients were analysed. Diagnoses of FM were determined by rheumatologists. Incidence rates were calculated, and Cox regression models were used to determine HRs for FM risk. The cumulative incidence rate was 6.77 (95% CI 5.19 to 8.64) per 100 person-years during the first 12 months after inflammatory arthritis diagnosis, and decreased to 3.58 (95% CI 1.86 to 6.17) per 100 person-years 12-24 months after arthritis diagnosis. Pain severity (HR 2.01, 95% CI 1.17 to 3.46) and poor mental health (HR 1.99, 95% CI 1.09 to 3.62) predicted FM risk. Citrullinated peptide positivity (HR 0.48, 95% CI 0.26 to 0.88) was associated with decreased FM risk. Serum inflammatory markers and swollen joint count were not significantly associated with FM risk. The incidence of FM was from 3.58 to 6.77 cases per 100 person-years, and was highest during the first 12 months after diagnosis of inflammatory arthritis. Although inflammation was not associated with the clinical diagnosis of FM, pain severity and poor mental health were associated with the clinical diagnosis of FM. Seropositivity was inversely associated with the clinical diagnosis of FM.

publication date

  • June 2013

has subject area

  • Adult
  • Aged
  • Antibodies
  • Arthritis
  • Arthritis, Rheumatoid
  • Canada
  • Cohort Studies
  • Female
  • Fibromyalgia
  • Humans
  • Incidence
  • Male
  • Mental Disorders
  • Middle Aged
  • Pain Measurement
  • Peptides, Cyclic
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Severity of Illness Index

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3488361

Digital Object Identifier (DOI)

  • 10.1136/annrheumdis-2012-201506

PubMed ID

  • 22791744

Additional Document Info

start page

  • 949

end page

  • 954

volume

  • 72

number

  • 6