MTORC1 signaling aids in CADalyzing pyrimidine biosynthesis Article uri icon

Overview

MeSH Major

  • Adaptor Proteins, Signal Transducing
  • Hepatocyte Growth Factor
  • MicroRNAs
  • Phosphoproteins
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins

abstract

  • Mechanistic target of rapamycin complex 1 (mTORC1) regulates growth and metabolism by integrating signals from the cellular environment. Ben-Sahra et al. (2013) and Robitaille et al. (2013) demonstrate a role for mTORC1 in nucleotide production via S6K1 phosphorylation of CAD, which catalyzes the initial steps of de novo pyrimidine biosynthesis.

publication date

  • May 7, 2013

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2013.04.018

Additional Document Info

start page

  • 633

end page

  • 5

volume

  • 17

number

  • 5