MTORC1 signaling aids in CADalyzing pyrimidine biosynthesis
Adaptor Proteins, Signal Transducing
Hepatocyte Growth Factor
Mechanistic target of rapamycin complex 1 (mTORC1) regulates growth and metabolism by integrating signals from the cellular environment. Ben-Sahra et al. (2013) and Robitaille et al. (2013) demonstrate a role for mTORC1 in nucleotide production via S6K1 phosphorylation of CAD, which catalyzes the initial steps of de novo pyrimidine biosynthesis.