Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity. Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Epigenomics
  • Protein-Arginine N-Methyltransferases

abstract

  • Although it is known to be an ER cofactor in breast cancer, CARM1 expression levels are independent of ER. CARM1 has distinct functions among molecular subtypes, as is indicative of its sub-cellular localization and it may function in subtype etiology. These sub-cellular localization patterns, indicate a novel role beyond its ER cofactor function in breast cancer. Differential localization among ethnic groups may be due to ancestry-specific polymorphisms which alter the gene product.

publication date

  • January 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3663705

Digital Object Identifier (DOI)

  • 10.1186/1476-4598-12-40

PubMed ID

  • 23663560

Additional Document Info

start page

  • 40

volume

  • 12

number

  • 1