Minireview: Obesity and breast cancer: A Tale of inflammation and dysregulated metabolism Review uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Inflammation
  • Obesity

abstract

  • In addition to the spectrum of conditions known collectively as the Metabolic Syndrome, obesity is now recognized to be associated with increased risk of several cancers including colon, endometrial, and breast cancer. Obesity and carcinogenesis share 2 characteristics in common. On the one hand, they involve inflammatory pathways, and on the other hand, they involve dysregulated metabolism. In this review we focus on postmenopausal breast cancer and discuss the metabolic and cellular mechanisms whereby obesity and breast cancer are related. Because a majority of postmenopausal breast tumors are estrogen responsive, we include a discussion of the action of obesity-related factors on estrogen formation within the breast.

publication date

  • May 2013

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC5416759

Digital Object Identifier (DOI)

  • 10.1210/me.2013-1011

PubMed ID

  • 23518927

Additional Document Info

start page

  • 715

end page

  • 25

volume

  • 27

number

  • 5