Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines Academic Article uri icon


MeSH Major

  • Influenza Vaccines
  • Influenza, Human
  • Interferons
  • Orthomyxoviridae
  • Pneumococcal Infections
  • Pneumococcal Vaccines
  • Streptococcus pneumoniae


  • Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.


publication date

  • April 18, 2013



  • Academic Article



  • eng

PubMed Central ID

  • PMC3681204

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2012.12.008

PubMed ID

  • 23601689

Additional Document Info

start page

  • 831

end page

  • 44


  • 38


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