Biological relevance of inflammation and oxidative stress in the pathogenesis of arterial diseases. Review uri icon

Overview

MeSH

  • Animals
  • Atherosclerosis
  • Biomarkers
  • Humans
  • Obesity

MeSH Major

  • Inflammation
  • Oxidative Stress
  • Vascular Diseases

abstract

  • Over the past three decades, age-adjusted rates of cardiovascular morbidity and mortality have fallen in the United States, but the prevalence of obesity and associated metabolic disorders has risen dramatically. Recent studies have begun to unravel the complex linkages between adipose and vascular tissues that may accelerate the development of atherosclerosis in the context of obesity. Experimental models indicate that inflammation and oxidative stress, which mutually amplify each other within the vasculature and in visceral fat, are key processes that drive the initiation, progression, and subsequent rupture of the atherosclerotic lesion. Emerging research is further elucidating the contributions made by chemokines and their receptors, adipokines, and miRNAs to arterial disease. Translation of these basic science findings to clinical applications represents a tantalizing possibility for reducing the global burden of obesity-associated atherosclerosis and other cardiovascular diseases. Copyright © 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

publication date

  • May 2013

has subject area

  • Animals
  • Atherosclerosis
  • Biomarkers
  • Humans
  • Inflammation
  • Obesity
  • Oxidative Stress
  • Vascular Diseases

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3644714

Digital Object Identifier (DOI)

  • 10.1016/j.ajpath.2013.01.010

PubMed ID

  • 23608224

Additional Document Info

start page

  • 1474

end page

  • 1481

volume

  • 182

number

  • 5