Hedgehog pathway inhibition radiosensitizes non-small cell lung cancers Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Non-Small-Cell Lung
  • Hedgehog Proteins
  • Lung Neoplasms
  • Neoplasm Proteins
  • Radiation Tolerance

abstract

  • Targeted Hedgehog pathway inhibition can increase in vivo radiation efficacy in lung cancer preclinical models. This effect is associated with pathway suppression in tumor-associated stroma. These data support clinical testing of Hedgehog inhibitors as a component of multimodality therapy for locally advanced non-small cell lung cancer.

publication date

  • May 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4145860

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2012.10.014

PubMed ID

  • 23182391

Additional Document Info

start page

  • 143

end page

  • 9

volume

  • 86

number

  • 1