Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Renal Cell
  • Chromatin Assembly and Disassembly
  • Genes, Tumor Suppressor
  • Kidney Neoplasms
  • Mutation

abstract

  • Most mutations of chromatin modulators discovered in ccRCC are loss of function, associated with advanced stage, grade, and possibly worse CSS. Further studies validating the clinical impact of these novel mutations and future development of therapeutics remedying these tumor suppressors are warranted.

publication date

  • May 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3615105

Digital Object Identifier (DOI)

  • 10.1016/j.eururo.2012.09.005

PubMed ID

  • 23036577

Additional Document Info

start page

  • 848

end page

  • 54

volume

  • 63

number

  • 5