Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma
Carcinoma, Renal Cell
Chromatin Assembly and Disassembly
Genes, Tumor Suppressor
Most mutations of chromatin modulators discovered in ccRCC are loss of function, associated with advanced stage, grade, and possibly worse CSS. Further studies validating the clinical impact of these novel mutations and future development of therapeutics remedying these tumor suppressors are warranted.