Stem cell metabolism in tissue development and aging Review uri icon

Overview

MeSH Major

  • Blastocyst
  • Cell Aging
  • Gene Expression Regulation, Developmental
  • Pluripotent Stem Cells

abstract

  • Recent advances in metabolomics and computational analysis have deepened our appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to be a mere consequence of the state of a cell, metabolism is now known to play a pivotal role in dictating whether a cell proliferates, differentiates or remains quiescent. Here, we review recent studies of metabolism in stem cells that have revealed a shift in the balance between glycolysis, mitochondrial oxidative phosphorylation and oxidative stress during the maturation of adult stem cells, and during the reprogramming of somatic cells to pluripotency. These insights promise to inform strategies for the directed differentiation of stem cells and to offer the potential for novel metabolic or pharmacological therapies to enhance regeneration and the treatment of degenerative disease.

publication date

  • June 15, 2013

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3666381

Digital Object Identifier (DOI)

  • 10.1242/dev.091777

PubMed ID

  • 23715547

Additional Document Info

start page

  • 2535

end page

  • 47

volume

  • 140

number

  • 12