Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer Academic Article uri icon

Overview

MeSH Major

  • Carcinoma
  • DNA Mutational Analysis
  • Proto-Oncogene Proteins B-raf
  • Thyroid Neoplasms

abstract

  • In this retrospective multicenter study, the presence of the BRAF V600E mutation was significantly associated with increased cancer-related mortality among patients with PTC. Because overall mortality in PTC is low and the association was not independent of tumor features, how to use BRAF V600E to manage mortality risk in patients with PTC is unclear. These findings support further investigation of the prognostic and therapeutic implications of BRAF V600E status in PTC.

authors

publication date

  • April 10, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3791140

Digital Object Identifier (DOI)

  • 10.1001/jama.2013.3190

PubMed ID

  • 23571588

Additional Document Info

start page

  • 1493

end page

  • 501

volume

  • 309

number

  • 14