Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk Academic Article uri icon

Overview

MeSH Major

  • Arrhythmias, Cardiac
  • Genetic Markers
  • Genome-Wide Association Study
  • Heart Conduction System
  • Heart Rate

abstract

  • We conclude that DNA biobanks coupled to electronic medical records not only provide a platform for genome-wide association study but also may allow broad interrogation of the longitudinal incidence of disease associated with genetic variants. The phenome-wide association study approach implicated sodium channel variants modulating QRS duration in subjects without cardiac disease as predictors of subsequent arrhythmias.

authors

publication date

  • April 2, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3713791

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.112.000604

PubMed ID

  • 23463857

Additional Document Info

start page

  • 1377

end page

  • 85

volume

  • 127

number

  • 13