Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk
Genome-Wide Association Study
Heart Conduction System
We conclude that DNA biobanks coupled to electronic medical records not only provide a platform for genome-wide association study but also may allow broad interrogation of the longitudinal incidence of disease associated with genetic variants. The phenome-wide association study approach implicated sodium channel variants modulating QRS duration in subjects without cardiac disease as predictors of subsequent arrhythmias.