HIF-1α stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma Academic Article uri icon

Overview

MeSH Major

  • Adipose Tissue
  • Aromatase
  • Breast Neoplasms
  • Dinoprostone
  • Gene Expression Regulation, Neoplastic
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Stromal Cells

abstract

  • This study is the first to identify HIF-1α as a modulator of PII-driven aromatase expression in human breast tumor-associated stroma and provides a novel mechanism for estrogen regulation in obesity-related, post-menopausal breast cancer. Together with our on-going studies on the role of AMP-activated protein kinase (AMPK) in the regulation of breast aromatase, this work provides another link between disregulated metabolism and breast cancer.

publication date

  • April 8, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3672802

Digital Object Identifier (DOI)

  • 10.1186/bcr3410

PubMed ID

  • 23566437

Additional Document Info

start page

  • R30

volume

  • 15

number

  • 2