HIF-1α stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma
Gene Expression Regulation, Neoplastic
Hypoxia-Inducible Factor 1, alpha Subunit
This study is the first to identify HIF-1α as a modulator of PII-driven aromatase expression in human breast tumor-associated stroma and provides a novel mechanism for estrogen regulation in obesity-related, post-menopausal breast cancer. Together with our on-going studies on the role of AMP-activated protein kinase (AMPK) in the regulation of breast aromatase, this work provides another link between disregulated metabolism and breast cancer.