An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress Review uri icon


MeSH Major

  • Ketoglutarate Dehydrogenase Complex
  • Mitochondria
  • Oxidative Stress


  • The activity of mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) is severely reduced in human pathologies where oxidative stress is traditionally thought to play an important role, such as familial and sporadic forms of Alzheimer's disease and other age-related neurodegenerative diseases. This minireview is focused on substantial data that were accumulated over the last 2 decades to support the concept that KGDHC can be a primary mitochondrial target of oxidative stress and at the same time a key contributor to it by producing reactive oxygen species. This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'.

publication date

  • July 2013



  • Review



  • eng

PubMed Central ID

  • PMC3563721

Digital Object Identifier (DOI)

  • 10.1016/j.mcn.2012.07.005

PubMed ID

  • 22820180

Additional Document Info

start page

  • 13

end page

  • 6


  • 55