Cancer metabolism: Fatty acid oxidation in the limelight Review uri icon

Overview

MeSH Major

  • Fatty Acids
  • Neoplasms

abstract

  • Warburg suggested that the alterations in metabolism that he observed in cancer cells were due to the malfunction of mitochondria. In the past decade, we have revisited this idea and reached a better understanding of the 'metabolic switch' in cancer cells, including the intimate and causal relationship between cancer genes and metabolic alterations, and their potential to be targeted for cancer treatment. However, the vast majority of the research into cancer metabolism has been limited to a handful of metabolic pathways, while other pathways have remained in the dark. This Progress article brings to light the important contribution of fatty acid oxidation to cancer cell function.

publication date

  • April 2013

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3766957

Digital Object Identifier (DOI)

  • 10.1038/nrc3483

PubMed ID

  • 23446547

Additional Document Info

start page

  • 227

end page

  • 32

volume

  • 13

number

  • 4