Microfluidic cell sorter (μFCS) for on-chip capture and analysis of single cells Academic Article uri icon

Overview

MeSH Major

  • Biological Assay
  • Cell Separation
  • Flow Cytometry
  • Microfluidic Analytical Techniques
  • Neoplastic Cells, Circulating

abstract

  • A low-cost and rapid microfluidic cell sorter (μFCS) for circulating tumor cell (CTC) detection, culture and analyses is developed. Based on size separation and molecular characterization, μFCS efficiently enriches CTCs from unprocessed whole blood, allows on-chip culture and molecular profiling, and provides cell retrieval for subsequent analyses. The potential clinical application of the technology is demonstrated by capturing and genetically analyzing CTCs in tumor-bearing mice.

publication date

  • July 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3508764

Digital Object Identifier (DOI)

  • 10.1002/adhm.201200046

PubMed ID

  • 23184773

Additional Document Info

start page

  • 432

end page

  • 6

volume

  • 1

number

  • 4