Clinical impact of immune microenvironment in stage i lung adenocarcinoma: Tumor interleukin-12 receptor β2 (IL-12Rβ2), IL-7R, and stromal FoxP3/CD3 ratio are independent predictors of recurrence Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Antigens, CD3
  • Biomarkers, Tumor
  • Forkhead Transcription Factors
  • Lung Neoplasms
  • Neoplasm Recurrence, Local
  • Receptors, Interleukin-12
  • Receptors, Interleukin-7

abstract

  • Our investigation confirms the biologic and prognostic significance of the tumor immune microenvironment for patients with stage I lung ADC and provides support for its use to stratify clinical outcome and immunotherapeutic interventions.

publication date

  • February 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3731922

Digital Object Identifier (DOI)

  • 10.1200/JCO.2012.45.2052

PubMed ID

  • 23269987

Additional Document Info

start page

  • 490

end page

  • 8

volume

  • 31

number

  • 4