Risk of asynchronous contralateral breast cancer in noncarriers of BRCA1 and BRCA2 mutations with a family history of breast cancer: A report from the women's environmental cancer and radiation epidemiology study Academic Article uri icon


MeSH Major

  • Breast Neoplasms
  • Neoplasms, Second Primary


  • Young women with breast cancer who have a family history of breast cancer and who test negative for deleterious mutations in BRCA1 and BRCA2 are at significantly greater risk of CBC than other breast cancer survivors. This risk varies with diagnosis age, family history of CBC, and degree of relationship to an affected relative. Women with a first-degree family history of bilateral disease have risks of CBC similar to mutation carriers. This has important implications for the clinical management of patients with breast cancer with family history of the disease.

publication date

  • February 2013



  • Academic Article



  • eng

PubMed Central ID

  • PMC3731919

Digital Object Identifier (DOI)

  • 10.1200/JCO.2012.43.2013

PubMed ID

  • 23269995

Additional Document Info

start page

  • 433

end page

  • 9


  • 31


  • 4