Pancreatic neuroendocrine paraneoplastic optic neuropathy: Confirmation with antibody to optic nerve and hepatic metastasis Academic Article uri icon

Overview

MeSH Major

  • Neuroendocrine Tumors
  • Optic Nerve
  • Optic Nerve Diseases
  • Pancreatic Neoplasms
  • Paraneoplastic Syndromes, Ocular
  • Vision Disorders

abstract

  • A 68-year-old woman presented with bilateral visual loss as the only clinical manifestation of an occult pancreatic nonsecretory neuroendocrine tumor (NET). The suspected diagnosis of paraneoplastic optic neuropathy was confirmed using immunofluorescence assays to demonstrate the presence of antibodies in the patient's serum that reacted with antigen(s) in the optic nerve and in the pancreatic NET hepatic metastasis. Treatment of the underlying cancer was followed by marked improvement in visual function.

publication date

  • March 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/WNO.0b013e3182699b2a

PubMed ID

  • 22926698

Additional Document Info

start page

  • 21

end page

  • 5

volume

  • 33

number

  • 1