TGFβRIIb mutations trigger aortic aneurysm pathogenesis by altering transforming growth factor β2 signal transduction Academic Article uri icon

Overview

MeSH Major

  • Aortic Aneurysm, Thoracic
  • Genetic Predisposition to Disease
  • Mutation
  • Protein-Serine-Threonine Kinases
  • Receptors, Transforming Growth Factor beta
  • Signal Transduction
  • Transforming Growth Factor beta2

abstract

  • We propose that TGFβRIIb expression is a regulatory mechanism for TGFβ2 signal transduction. Dysregulation of the TGFβ2 signaling pathway, as a consequence of TGFβRIIb mutations, results in aortic aneurysm pathogenesis.

publication date

  • December 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3547593

Digital Object Identifier (DOI)

  • 10.1161/CIRCGENETICS.112.964064

PubMed ID

  • 23099432

Additional Document Info

start page

  • 621

end page

  • 9

volume

  • 5

number

  • 6