Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Medullary
  • Exome
  • Mutation
  • Proto-Oncogene Proteins c-ret
  • Proto-Oncogene Proteins p21(ras)
  • Thyroid Neoplasms

abstract

  • Approximately 90% of MTCs had mutually exclusive mutations in RET, HRAS, and KRAS, suggesting that RET and RAS are the predominant driver pathways in MTC. Relatively few mutations overall and no commonly recurrent driver mutations other than RET, HRAS, and KRAS were seen in the MTC exome.

publication date

  • February 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3565108

Digital Object Identifier (DOI)

  • 10.1210/jc.2012-2703

PubMed ID

  • 23264394

Additional Document Info

start page

  • E364

end page

  • 9

volume

  • 98

number

  • 2