Candidate Sequence Variants and Fetal Hemoglobin in Children with Sickle Cell Disease Treated with Hydroxyurea Academic Article uri icon

Overview

MeSH Major

  • Anemia, Sickle Cell
  • Antisickling Agents
  • Fetal Hemoglobin
  • Hydroxyurea
  • Polymorphism, Single Nucleotide

abstract

  • These findings clarify the overlap between baseline and hydroxyurea-induced fetal hemoglobin levels in pediatric disease. Studies assessing influences of specific sequence variants in these and other genetic loci in larger populations and in unusual hydroxyurea responders are needed to further understand the maintenance and therapeutic induction of fetal hemoglobin in pediatric sickle cell disease.

publication date

  • February 7, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3567082

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0055709

PubMed ID

  • 23409025

Additional Document Info

start page

  • e55709

volume

  • 8

number

  • 2