Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques Academic Article uri icon

Overview

MeSH Major

  • Cyclohexanes
  • HIV Fusion Inhibitors
  • Simian Acquired Immunodeficiency Syndrome
  • Triazoles
  • Vaginal Creams, Foams, and Jellies

abstract

  • A high degree of correlation between PK and efficacy was observed. Based on the data obtained with the 3.3% w/w maraviroc gel, maintenance of vaginal fluid and tissue levels in the order of 10(7) ng/mL and 10(3) ng/g, respectively, are required for complete protection with this compound.

publication date

  • March 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3566668

Digital Object Identifier (DOI)

  • 10.1093/jac/dks422

PubMed ID

  • 23111849

Additional Document Info

start page

  • 678

end page

  • 83

volume

  • 68

number

  • 3