Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques
HIV Fusion Inhibitors
Simian Acquired Immunodeficiency Syndrome
Vaginal Creams, Foams, and Jellies
A high degree of correlation between PK and efficacy was observed. Based on the data obtained with the 3.3% w/w maraviroc gel, maintenance of vaginal fluid and tissue levels in the order of 10(7) ng/mL and 10(3) ng/g, respectively, are required for complete protection with this compound.