Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition
Embryonic Stem Cells
Hematopoietic Stem Cells
Live imaging of endothelial to hematopoietic conversion identifies distinct subpopulations of hESC-derived hemogenic endothelium. Expression of the Notch ligand DII4 on vascular ECs drives induction of myeloid fate from hESC-derived hematopoietic progenitors.