Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition Academic Article uri icon

Overview

MeSH Major

  • Cell Differentiation
  • Embryonic Stem Cells
  • Endothelial Cells
  • Hematopoietic Stem Cells
  • Transduction, Genetic

abstract

  • Live imaging of endothelial to hematopoietic conversion identifies distinct subpopulations of hESC-derived hemogenic endothelium. Expression of the Notch ligand DII4 on vascular ECs drives induction of myeloid fate from hESC-derived hematopoietic progenitors.

publication date

  • January 31, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1182/blood-2012-07-444208

PubMed ID

  • 23169780

Additional Document Info

start page

  • 770

end page

  • 80

volume

  • 121

number

  • 5