Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors Academic Article uri icon

Overview

MeSH Major

  • Exome
  • Gene Fusion
  • Genetic Variation
  • Neoplasm Proteins
  • Repressor Proteins
  • STAT6 Transcription Factor
  • Solitary Fibrous Tumors

abstract

  • Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.

publication date

  • February 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3984043

Digital Object Identifier (DOI)

  • 10.1038/ng.2522

PubMed ID

  • 23313954

Additional Document Info

start page

  • 131

end page

  • 2

volume

  • 45

number

  • 2