Increased leucocyte apoptosis in transfused β-thalassaemia patients Academic Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Leukocytes
  • beta-Thalassemia

abstract

  • This exploratory study assessed apoptosis in peripheral blood leucocytes (PBL) from β-thalassaemia patients receiving chronic transfusions and chelation therapy (deferasirox or deferoxamine) at baseline, 1, 6, and 12 months. At baseline, thalassaemic PBLs presented 50% greater levels of Bax (BAX), 75% higher caspase-3/7, 48% higher caspase-8 and 88% higher caspase-9 activities and 428% more nucleosomal DNA fragmentation than control subjects. Only neutrophils correlated significantly with apoptotic markers. Previously, we showed that over the treatment year, hepatic iron declined; we now show that the ratio of Bax/Bcl-2 (BCL2), (-27·3%/year), and caspase-9 activity (-13·3%/year) declined in both treatment groups, suggesting that chelation decreases body iron and indicators of PBL apoptosis.

publication date

  • February 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4597914

Digital Object Identifier (DOI)

  • 10.1111/bjh.12076

PubMed ID

  • 23216540

Additional Document Info

start page

  • 399

end page

  • 403

volume

  • 160

number

  • 3